I have seen the nD page before. There's no way it is a real thing. It's a creative writing exercise or a sad sad make believe world.

My current concept for the game is an exploration/collecting game with some metroidvania style unlockable abilities that help you uncover new areas. Combat would be limited to super mario style jumping on baddies or avoiding them. I'd like to have a casual mode that removes most enemies, so the game should stand on the exploration, platforming and puzzles alone.

The four girls are established characters in this comic series. Here they have been placed into the role of the left 4 dead survivors for the purpose of making a joke about the game. This is common practice. A very similar example from the comic "rooster teeth" can be seen here http://www.tacticalsites.com/skylark/pics/L4Dcomic2.jpg

In the United States, "Ms." is the default form of address for women, regardless of marital status (as opposed to "Mrs." which applies exclusively to married women). The "Ms." names in the transcript are simply there to match the dialog to a character and are often played for laughs as well.

MegaScience, you've forced me to have these sorts of remedial interactions with you for several years now. For my personal records, please answer the following questions:
- How old are you?
- Have you ever been diagnosed with any kind of mental condition?
- Are you on any kind of medication?
- Are you or have you been home-schooled? For how long?